Cas No: 1841081-72-8 Manufacturers

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Understanding CAS No: 1841081-72-8 and Its Manufacturers
In the world of pharmaceuticals and fine chemicals, certain compounds play a crucial role in the development and production of active pharmaceutical ingredients (APIs). One such compound is CAS No: 1841081-72-8, which is also known by its chemical name: 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride. This compound is often referred to as Bilastine Impurity 27 HCl, as it is closely related to the synthesis and quality control processes of the antihistamine drug Bilastine.
While this compound might not be widely known outside of chemical and pharmaceutical circles, it is an essential intermediate and reference standard. In this blog, we’ll explore the significance of CAS No: 1841081-72-8, the type of manufacturers involved in its production, and what to consider when sourcing it — without focusing on any specific brand or company.

What Is CAS No: 1841081-72-8?
CAS No: 1841081-72-8 is a hydrochloride salt form of a benzimidazole derivative. It is most commonly used as an intermediate in the synthesis of Bilastine, a second-generation ...
... antihistamine.
In addition to its role in synthesis, this compound is also used as an impurity reference standard. During quality control and regulatory testing of Bilastine, known impurities like this one are measured and monitored to ensure drug safety and compliance with pharmacopeial standards such as USP, EP, or ICH guidelines.
Chemical Properties at a Glance
Chemical Name: 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride

Molecular Formula: C16H24ClN3O

Molecular Weight: Approximately 309.83 g/mol

Purity: Generally offered at ≥97%, sometimes higher depending on the supplier

Storage Conditions: Room temperature or 2–8°C depending on usage (analytical vs. synthetic)

Why Is It Important?
This compound is important for a few reasons:
Pharmaceutical Synthesis: It plays a vital role as an intermediate during the chemical synthesis of Bilastine. Without it, the production process would not be complete.

Impurity Profiling: During drug development and manufacturing, pharmaceutical companies need to detect and quantify any impurities that may arise. Known impurities such as CAS No: 1841081-72-8 are used as reference standards to validate analytical methods.

Regulatory Compliance: To meet the strict regulations of authorities like the FDA or EMA, drug manufacturers must identify, quantify, and control all known and potential impurities in their products. This compound helps in fulfilling those requirements.

Who Manufactures It?
Many manufacturers across the globe produce CAS No: 1841081-72-8. These include:
Contract research organizations (CROs): These companies specialize in producing research-grade chemicals and pharmaceutical intermediates. They often offer custom synthesis and bulk manufacturing services.

Contract development and manufacturing organizations (CDMOs): These entities handle the development and production of complex chemical compounds, often under GMP (Good Manufacturing Practice) conditions.

Fine chemical producers: These companies provide high-purity chemicals used in research and manufacturing, including pharmaceutical intermediates and impurity standards.

Analytical and reference material suppliers: Some companies produce this compound specifically for use as a reference impurity standard in laboratory settings.

Regions of Production
Most of the global supply of CAS No: 1841081-72-8 comes from established chemical hubs such as:
India: Known for its large pharmaceutical manufacturing base, India has many producers that offer intermediates like this one at both lab and industrial scale.

China: With its expansive chemical manufacturing infrastructure, China supplies a significant portion of the world’s intermediates and raw materials.

Europe & North America: These regions are home to high-end manufacturers who may specialize in GMP-compliant production for regulatory-grade material.

Each region offers different benefits. While Asian suppliers often offer competitive pricing and scalable production, Western manufacturers may focus more on compliance, documentation, and high-end quality systems.
What to Look for in a Manufacturer
When choosing a manufacturer or supplier for CAS No: 1841081-72-8, several key factors should be considered:
1. Purity and Quality
A high level of purity (typically ≥97%) is essential, especially if the compound is being used as an impurity standard or in a clinical setting. Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and spectroscopic data (like HPLC or NMR) should be available.
2. Regulatory Compliance
Depending on the intended use, it may be important to ensure the manufacturer follows GMP guidelines, and can provide documentation needed for regulatory submissions.
3. Batch Consistency
Consistency between batches is vital for reliable laboratory results and pharmaceutical applications. Reputable manufacturers will have robust quality control systems in place.
4. Logistics and Packaging
Because some chemicals are sensitive to moisture, light, or temperature, proper packaging and shipping (including cold-chain options when needed) are necessary. Manufacturers should also be able to ship with clear labeling and handling instructions.
5. Customization Options
For unique research or pilot projects, it may be helpful if the supplier offers custom synthesis services or the ability to produce the compound in specific quantities or purity grades.
Common Uses
Bilastine API Production: It’s a crucial intermediate in the multi-step synthesis of Bilastine.

Analytical Testing: Used as a known impurity to develop and validate testing methods.

Regulatory Filing Support: Helps meet international standards for impurity profiling.

Final Thoughts
Although not a finished drug or widely recognized outside the industry, CAS No: 1841081-72-8 is an important part of pharmaceutical manufacturing and quality assurance. Whether used as a synthetic intermediate or a reference impurity, this compound supports the safety, consistency, and efficacy of final pharmaceutical products like Bilastine.
Choosing the right manufacturer involves careful evaluation of purity, documentation, compliance, and reliability. While many options exist across different regions, the most suitable supplier will depend on your specific needs—whether research, development, or commercial production.
As regulatory expectations rise and quality standards tighten, the importance of sourcing reliable, high-quality intermediates like CAS No: 1841081-72-8 continues to grow.
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