Precautions Of Deflazacort

By Author: sudarshan singh
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Deflazacort is a glucocorticold. Its anti inflammatory and immunosuppressive effects are used in treating a variety of disease and are comparable to other antiinflammtory steroids. Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It is sold in the United Kingdom by Shire under the trade name Calcort, in Brazil as Cortax, Decortil, and Deflanil, and in Honduras as Flezacor. It is not available in the United States. Deflazacort is a prodrug. Its potency is around 70–90% that of prednisone.

* Rheumatoid Arthritis & Juvenile Chronic Arthritis, Asthma and other airway diseases, Pemphigus, Uveitis, Nephrotic Syndrome, immunne suppression in transplantation.
* Patients.
* Hypersensitivity.

The dosage should be individually titrated according to diagnosis, severity of disease and patient response and tolerance. The lowest dose that will produce an acceptable response should be used.

Adults: For acute disorders, up to 120mg/day. deflazacort may need to be given initially. Maintainance ...
... dosese in most conditions are within the range 3-18mg/day. Children: In children, the indications for glucocorticoids are the same as for adults, but it is important that the lowest effective dosage is used. Alternate day administration may be appropriate. Doses of deflazacort usually lie in the 0.25-1.5mg/ kg/day.

Precautions while prescribing Deflazacort (Cortax and Decortil)

* Gastritis or oesophagitis, diverticulitis, ulcerative colitis if there is probalility of impending perforation, abscess or pyogenic infections, fresh intestinal anastomsis, active or latent peptic ulcer.
* Emotional instability or psychotic tendency, epilepsy.
* Adrenal suppression, Cardiac diseases or congestive heart failure (except in the presence of active rheumatic carditis), hypertension, thromboembolic disorders.
* Diabetic mellitus or a family history, osteoporosis, (nyasthenia gravis, renal insufficiency.
* Previous corticosteroidinduced myopathy, Liver failure, Hypothyroidism and cirrhosis, Ocular herpes simplex, pregnant woman, lactation.

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It is sold in the United Kingdom by Shire under the trade name Calcort,in Brazil as Cortax, Decortil, and Deflanil, and in Honduras as Flezacor. It is not available in the United States.Deflazacort is a prodrug. Its potency is around 70–90% that of prednisone.Deflazacort is a corticosteroid used to treat a variety of inflammatory and allergy related health conditions, such as rheumatoid arthritis and asthma.Deflazacort works by blocking the body's release of chemicals which cause inflammation and allergic reaction. drenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.

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