What Is Arestin? A Simple Guide To Gum Disease Treatment

By Author: Perio PDX
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Periodontal (gum) disease affects millions of people worldwide and is a leading cause of adult tooth loss. It begins when plaque and tartar build up along the gumline, leading to inflammation and infection. If not treated, gum disease can cause gums to recede, teeth to loosen, and even bone loss.
Traditional treatment often starts with scaling and root planing (SRP)—a deep-cleaning procedure that removes plaque and tartar from below the gumline. While SRP is effective, some gum pockets may still harbor harmful bacteria. That’s where Arestin comes in.
What Is Arestin?
Arestin is an FDA-approved, locally applied antibiotic used alongside SRP to fight gum disease. Its active ingredient is minocycline hydrochloride, an antibiotic known for its ability to target bacteria that cause periodontal infections.
Unlike oral antibiotics, which spread throughout the entire body, Arestin works directly at the infection site. This makes treatment more precise, effective, and reduces the chance of systemic side effects.
How Arestin Works: The Science
Microsphere Technology: Arestin is made up of tiny biodegradable ...
... microspheres filled with minocycline.

Direct Application: During SRP, your periodontist gently places these microspheres into deep gum pockets.

Controlled Release: The antibiotic is slowly released over time, continuing to fight bacteria for weeks.

Healing Support: With fewer bacteria, gums can begin to heal and reattach to teeth.

Benefits of Arestin
✅ Targeted Action – Works where bacteria hide most: deep gum pockets.
✅ Enhanced SRP Results – Improves the effectiveness of deep cleaning.
✅ Long-Lasting Protection – Continues to work for up to 21 days after treatment.
✅ Non-Surgical Option – Provides advanced results without invasive procedures.
✅ Better Gum Health – Reduces inflammation and pocket depth for stronger gums.
Is Arestin Safe?
Yes, Arestin has been clinically tested and is safe for most patients. Because it’s applied locally, the risk of systemic side effects is low compared to oral antibiotics.
Possible mild side effects may include:
Gum irritation

Redness or swelling near the application site

Mild tooth sensitivity

These are usually temporary and go away as the gums heal.
Your periodontist will review your medical history to ensure that Arestin is right for you, especially if you are pregnant, nursing, or allergic to tetracyclines.
Who Should Consider Arestin?
Arestin may be recommended for patients who:
Have moderate to severe periodontal disease

Struggle with deep gum pockets that don’t respond to SRP alone

Want a non-surgical approach to gum care

Are looking to protect teeth and bone structure from further damage

What to Expect During Treatment
Scaling & Root Planing (SRP): Your gums are cleaned thoroughly to remove plaque and tartar.

Application: Arestin microspheres are gently placed into infected gum pockets with a small applicator.

Healing Process: The medication slowly releases antibiotics, fighting infection over several weeks.

Follow-Up Care: Your periodontist monitors healing and may recommend maintenance cleanings.

Frequently Asked Questions (FAQs)
1. Does Arestin hurt?
No. Arestin is applied gently and painlessly during SRP. Most patients don’t feel anything.
2. How long does Arestin last?
It continues to fight bacteria for about 21 days, giving gums time to heal.
3. Can I eat right after treatment?
You should avoid hard, crunchy, or sticky foods for the first few days to prevent dislodging the medicine.
4. Is Arestin better than oral antibiotics?
Yes, because it works locally where bacteria live, instead of spreading throughout the body.
5. Do I still need to brush and floss?
Absolutely. Arestin is not a substitute for good oral hygiene—it works best with daily brushing, flossing, and regular dental visits.
Why Choose Arestin?
Gum disease can have serious consequences, not just for your oral health but also for your overall health. Studies link periodontal disease to heart disease, diabetes, and other conditions. Arestin offers a safe, targeted, and effective way to reduce infection and improve gum health—helping you keep your natural teeth longer.
At Perio PDX, we proudly offer Arestin as part of our advanced periodontal care. Our goal is to protect your smile with the latest, most effective treatments available.

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