Cas No: 147128-77-6 Manufacturers

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Exploring CAS No: 147128-77-6 and Its Global Manufacturers
The global chemical and pharmaceutical industries are supported by a vast network of intermediates and active compounds, many of which play a crucial role in the synthesis of life-saving drugs. One such intermediate is CAS No: 147128-77-6, a chiral sulfone compound used primarily in the production of certain pharmaceutical products. This blog explores what this compound is, how it’s used, the considerations for manufacturing it, and the general landscape of manufacturers around the world—without focusing on any particular company.

What is CAS No: 147128-77-6?
CAS No: 147128-77-6 refers to a specific chiral compound that plays a role in the synthesis of dorzolamide, a drug used to treat high intraocular pressure and glaucoma. The compound's IUPAC name is a bit of a mouthful: (4R,6S)-4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-7,7-dioxide. It contains sulfur, oxygen, and carbon atoms arranged in a complex bicyclic structure with two stereocenters, which makes the compound optically active.
The presence of stereochemistry (the "4R,6S" ...
... configuration) is critical. Many drugs and their intermediates are chiral, meaning that they can exist in two or more forms that are mirror images of each other. In pharmaceuticals, often only one stereoisomer is biologically active or safe. Therefore, the synthesis and manufacturing of this compound must be done with a high degree of control and precision to ensure the correct configuration is obtained and maintained.
Applications and Importance
The main application of CAS No: 147128-77-6 is in the synthesis of dorzolamide hydrochloride, a carbonic anhydrase inhibitor used in eye drops to reduce intraocular pressure. This drug is commonly prescribed for conditions such as open-angle glaucoma and ocular hypertension.
Because of its medical relevance, the intermediate must meet high standards of purity, consistency, and safety. This has implications for how and where it is manufactured. Facilities producing this intermediate must often comply with Good Manufacturing Practices (GMP), especially when the compound is part of a supply chain that ends in pharmaceutical formulations for human use.
Overview of the Manufacturing Process
Manufacturing CAS No: 147128-77-6 typically involves several steps of organic synthesis, including cyclization, sulfone formation, and stereochemical control. The process requires not only specialized reagents but also controlled conditions to ensure yield and purity.
The challenges in manufacturing this compound stem from:
Chiral synthesis or resolution: The need to isolate or synthesize a specific stereoisomer increases complexity.

Purity requirements: Impurities, especially incorrect stereoisomers or residual solvents, can compromise the safety or efficacy of the final pharmaceutical product.

Analytical controls: Techniques such as NMR spectroscopy, HPLC, and chiral chromatography are essential to verify quality and compliance.

Regulatory documentation: A full Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and often ICH-compliant stability data may be required for commercial use.

Due to these challenges, manufacturers of this compound are typically well-equipped chemical companies with capabilities in fine chemical synthesis, quality assurance, and regulatory compliance.
Key Considerations When Choosing a Manufacturer
For businesses or researchers looking to source CAS No: 147128-77-6, there are several factors to keep in mind:
Purity and Stereochemistry: Ensure that the material meets the required purity and that the correct stereoisomer is provided.

Batch Size: Depending on whether it’s needed for lab research or commercial production, manufacturers should be able to scale accordingly.

Documentation: Full documentation including CoA, MSDS, and possibly GMP certification should be available.

Lead Time and Availability: Some manufacturers maintain stock, while others may produce only on order.

Regulatory Compliance: For pharmaceutical applications, ensure that the manufacturer complies with local and international regulations.

Conclusion
CAS No: 147128-77-6 is a valuable intermediate in the pharmaceutical industry, especially in the synthesis of dorzolamide. Its chiral nature and role in medicine demand precision in its manufacturing, analysis, and regulatory handling. While global manufacturing of this compound is widespread, choosing the right supplier involves careful consideration of quality, compliance, cost, and reliability.
As the pharmaceutical landscape continues to evolve and demand for effective eye treatments grows, compounds like this will remain crucial. Manufacturers who can offer consistent quality and regulatory support will continue to play a vital role in the supply chain of modern medicine.
URL: For more information, visit Vasista Pharma: Cas No: 147128-77-6 Manufacturers