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Medicinal Chemistry And Drug Discovery | Integrated Drug Discovery Services

Medicinal Chemistry :
Medicinal chemistry within the realm of drug discovery involves the intricate process of conceiving and developing new medicines. While this journey is lengthy, complex, expensive, and risky, the potential benefits for millions of patients with serious illnesses serve as a constant driving force. Central to this effort is medicinal chemistry, a discipline that meticulously selects and crafts compounds. These compounds establish critical structure-activity relationships (SARs), ensuring efficacy and safety through preclinical in vitro, ex vivo and in vivo models.
Leveraging insights from Aryastha’s experience in honing the drug discovery process, a key improvement involves conducting more in vivo testing at an earlier stage. This advancement empowers medicinal chemists to champion their potential drug candidates. These medicinal chemists are essential team members of interdisciplinary groups, adept at foreseeing challenges in transitioning in vitro activity to in vivo and driving the project forward.
When a promising ‘HIT’ is identified, the medicinal chemist strategizes to explore ...
... the SARs within a structural compound family, thus optimizing desired biological activities. The medicinal chemist is also primarily responsible for establishing the hit compound’s effectiveness in a suitable preclinical model. This task is one of the most challenging phases involving a comprehensive study of LEAD compounds to comprehend absorption, in vivo distribution, metabolism rate, and excretion (ADME). The ultimate objective during this stage is to optimize the compound’s effectiveness while minimizing any potential adverse effects within the animal model.
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