Simparica Trio For Xlarge Dogs – Complete Guide For Pet Parents

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Caring for an extra-large dog is no small task—literally. Bigger breeds like Great Danes, Saint Bernards, Rottweilers, and Mastiffs require more food, more space, and more… parasite protection. That’s where Simparica TRIO for XLarge Dogs (88.1–132 lbs) comes in. This monthly chew offers triple protection against fleas, ticks, heartworms, and intestinal worms, making it one of the most comprehensive parasite preventatives on the market.

In this guide, we’ll walk you through everything you need to know—what it is, how it works, safety tips, and why it’s especially beneficial for large-breed dogs.

What is Simparica TRIO?
Simparica TRIO is a once-a-month, liver-flavored chewable tablet developed by Zoetis. It’s designed to provide broad-spectrum parasite protection with a single dose, replacing the need for multiple medications.

It contains three active ingredients:

Sarolaner – Kills fleas and ticks fast

Moxidectin – Prevents heartworm disease

Pyrantel pamoate – Treats ...
... and controls roundworms and hookworms

Why the “Extra Large” Version?
Simparica TRIO comes in different strengths based on your dog’s weight. The Extra Large version is formulated for dogs 88.1–132 lbs to ensure correct dosing and maximum safety.
The dosage contains:

Sarolaner: 72 mg

Moxidectin: 1.44 mg

Pyrantel (pamoate salt): 300 mg

How Does It Work?
Here’s how each ingredient in Simparica TRIO protects your dog:

Ingredient Role & Protection
Sarolaner Attacks the nervous system of fleas and ticks, killing fleas within 4 hours and ticks within 24 hours.
Moxidectin Prevents heartworm disease by killing immature heartworm larvae transmitted by mosquitoes.
Pyrantel Paralyzes and eliminates roundworms and hookworms from your dog’s intestinal tract.

Parasites Simparica TRIO Protects Against
Fleas – Kills adult fleas before they can lay eggs, breaking the life cycle.

Ticks – Effective against black-legged ticks, Lone Star ticks, Gulf Coast ticks, and more.

Heartworms – Prevents potentially deadly heartworm disease.

Roundworms & Hookworms – Treats and controls these common intestinal parasites.

Benefits for Extra-Large Dogs
All-in-One Protection – No need for separate flea, tick, and worm preventatives.

Tailored Dosage – Designed specifically for dogs over 88 lbs for safety and effectiveness.

Palatable Flavor – Liver-flavored chew that most dogs take like a treat.

Convenience – Just one tablet per month.

Fast Acting – Flea kill starts within hours.

How to Give Simparica TRIO
Give one chewable every month, ideally on the same date.

Can be given with or without food.

If your dog spits it out or misses a dose, give it as soon as possible and resume monthly dosing.

Safety Information
Age & Weight: Safe for dogs 8 weeks and older, weighing at least 2.8 lbs.

Side Effects: The most common include vomiting, diarrhea, and lethargy.

Neurological Caution: Use with caution in dogs with a history of seizures.

Breeding & Pregnant Dogs: Safety not established for breeding, pregnant, or lactating females.

Prescription Required: Only available through veterinarians in most countries.

Tips for Pet Parents of Big Dogs
Set Monthly Reminders – Parasite prevention is only effective if doses aren’t missed.

Weigh Your Dog Regularly – Ensure they’re still within the extra-large dosage range.

Combine with Year-Round Prevention – Even in colder months, parasites can still be a risk.

Final Thoughts
For pet parents of giant breeds, Simparica TRIO for XLarge Dogs offers peace of mind and simplified parasite prevention. With just one chew a month, you’re protecting your dog from fleas, ticks, heartworms, and intestinal worms—saving time, reducing stress, and ensuring your best friend stays healthy all year round.