Cas No. 35180-01-9 Manufacturers In India

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Understanding Chloromethyl Isopropyl Carbonate (CAS No. 35180-01-9): A Key Intermediate in Pharmaceutical Synthesis
The chemical industry is the cornerstone of modern science and technology, supplying essential compounds for industries ranging from agriculture to electronics. One niche but critical segment of this industry is the manufacturing of pharmaceutical intermediates—chemical compounds used in the synthesis of active pharmaceutical ingredients (APIs). One such intermediate that plays a pivotal role in antiviral drug synthesis is Chloromethyl Isopropyl Carbonate, identified by its Chemical Abstracts Service (CAS) number: 35180-01-9.

What is Chloromethyl Isopropyl Carbonate?
Chloromethyl Isopropyl Carbonate (CMIC) is an organic compound that exists as a colorless to pale yellow liquid. It belongs to the family of chloroformates, a group of chemicals often used in organic synthesis due to their reactivity with amines, alcohols, and acids. CMIC, in particular, is prized for its role as a reagent and intermediate in the pharmaceutical sector.
Its molecular formula is C5H9ClO3, and it has a molar ...
... mass of approximately 152.58 g/mol. This unique composition imparts specific reactivity that is highly valuable in drug synthesis.
Key Applications
The primary application of Chloromethyl Isopropyl Carbonate lies in its use as a chemical intermediate in the synthesis of Tenofovir, a crucial component in antiretroviral therapy (ART). Tenofovir is used in the treatment of HIV/AIDS and Hepatitis B, diseases that affect millions worldwide. In the synthetic route for Tenofovir, CMIC is involved in the preparation of Tenofovir disoproxil fumarate (TDF), a prodrug that enhances the bioavailability of Tenofovir.
Apart from Tenofovir, CMIC may also find use in the synthesis of other nucleotide analogues and advanced pharmaceutical compounds. Because it contains both a reactive carbonate and a chloroalkyl group, it can form ester and ether bonds under controlled conditions, enabling chemists to build complex molecules.
Chemical Properties and Handling
CMIC is a reactive chemical and must be handled with care. It is moisture-sensitive and should be stored under an inert atmosphere such as nitrogen. Prolonged exposure to air and water can result in hydrolysis, which degrades the compound and reduces its effectiveness in synthetic reactions.
Here are a few key properties:
Appearance: Colorless to pale yellow liquid
Boiling Point: Approximately 140–150°C (decomposes)
Solubility: Reacts with water; soluble in common organic solvents like dichloromethane and toluene
Stability: Stable under recommended storage conditions; decomposes on exposure to moisture
Given its reactivity, personal protective equipment (PPE) is essential during handling. This includes gloves, protective eyewear, lab coats, and proper ventilation to avoid inhalation of vapors.
Role in Green Chemistry and Process Optimization
Several process improvements have been made to minimize waste, reduce the use of toxic reagents, and enhance yield. The use of CMIC in pharmaceutical synthesis is now optimized to ensure higher atom economy and better resource utilization.
Continuous flow chemistry and catalysis have also been explored to enhance the efficiency of CMIC-based processes. These advances contribute not only to economic benefits but also to the reduction of environmental footprints in pharmaceutical manufacturing.
Regulatory Considerations
As with all compounds involved in pharmaceutical synthesis, the use and transport of CMIC are subject to stringent regulations. Manufacturers must comply with:
Good Manufacturing Practices (GMP)
REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) guidelines
Environmental Health and Safety (EHS) standards
Proper documentation, batch traceability, and impurity profiling are essential for CMIC, especially when the final product is intended for human consumption.
Furthermore, CMIC is not an end-product for direct human use, but because it plays a role in life-saving drug synthesis, regulatory bodies often scrutinize the quality and purity of this intermediate. Any impurities or deviations can significantly impact the efficacy or safety of the final drug formulation.
Global Demand and Market Trends
The demand for Chloromethyl Isopropyl Carbonate is directly tied to the production of Tenofovir and similar antiviral agents. With a growing global emphasis on public health and preparedness for viral epidemics, the market for CMIC has seen steady growth. Increased awareness and access to antiretroviral therapy in low- and middle-income countries have driven the need for large-scale, cost-effective production of pharmaceutical intermediates like CMIC.
In regions like Asia—particularly India and China—CMIC is produced in bulk quantities due to the established infrastructure for API and intermediate manufacturing. These countries have positioned themselves as global suppliers, fulfilling the needs of both domestic and international pharmaceutical firms.
Safety and Environmental Impact
While CMIC is a valuable intermediate, its use does carry some environmental and health risks if not managed properly. The compound must be neutralized and disposed of according to local environmental protection guidelines. Effluent treatment plants (ETPs) and scrubber systems are typically used to minimize emissions during manufacturing.
From a workplace safety perspective, training and operational controls are essential to prevent accidental exposure. Due to its potential to irritate the respiratory tract, skin, and eyes, emergency protocols and first-aid measures must be clearly communicated and accessible.
Conclusion
Chloromethyl Isopropyl Carbonate (CAS No. 35180-01-9) may not be a household name, but its role in the pharmaceutical world is significant and indispensable. As a key intermediate in the synthesis of Tenofovir, it plays a silent yet vital role in global health by aiding the production of drugs that fight life-threatening diseases like HIV and Hepatitis B.
The chemical’s reactivity, regulatory importance, and commercial demand underscore the need for high-quality, well-controlled manufacturing processes. With ongoing research into process efficiency and environmental sustainability, the future of CMIC production is poised to support the evolving needs of the pharmaceutical industry—more safely, sustainably, and effectively than ever before.
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