Cas No 138402 11 6 (irbesartÁn)

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Understanding CAS Number 138402-11-6: A Closer Look at Irbesartan
In the world of pharmaceuticals, each chemical compound is identified by a unique code known as the CAS number (Chemical Abstracts Service Number). One such compound that plays a critical role in the treatment of cardiovascular diseases is Irbesartan, identified by the CAS number 138402-11-6. This blog will explore the significance of Irbesartan, its uses, mechanism of action, and important considerations for its use.

What is Irbesartan?
Irbesartan is an angiotensin II receptor blocker (ARB) that is primarily used to treat conditions such as high blood pressure (hypertension) and diabetic nephropathy (kidney damage due to diabetes). As an ARB, it works by blocking the action of a hormone called angiotensin II, which constricts blood vessels. By inhibiting this hormone, Irbesartan helps to relax the blood vessels, leading to a decrease in blood pressure and improved blood flow.
Chemical Structure and Properties
Irbesartan is a non-peptide compound with a complex molecular structure. Its chemical formula is C25H28N6O. The compound ...
... contains an imidazole ring (which is part of its mechanism of action), a biphenyl group, and a tetrazole ring. These features allow it to selectively bind to the angiotensin II receptor, making it an effective treatment for hypertension and kidney protection in certain diabetic patients.
The CAS number 138402-11-6 is a unique identifier for Irbesartan in scientific databases, helping researchers, healthcare providers, and chemists to reliably locate and reference the compound.
Mechanism of Action
Irbesartan belongs to a class of medications known as angiotensin II receptor antagonists. It specifically binds to and blocks the AT1 receptor (a receptor for angiotensin II), which is responsible for many of the adverse effects of angiotensin II. When activated, this receptor causes blood vessels to constrict, leading to an increase in blood pressure and additional strain on the heart and kidneys.
By blocking the AT1 receptor, Irbesartan prevents vasoconstriction, reduces blood pressure, and alleviates the workload on the heart. This mechanism is especially beneficial in individuals with hypertension, and those suffering from conditions such as chronic kidney disease or diabetic nephropathy.
Therapeutic Uses
Irbesartan is most commonly prescribed for:
Hypertension (High Blood Pressure): As an effective antihypertensive drug, Irbesartan helps in lowering blood pressure, reducing the risk of complications such as stroke, heart attack, and kidney failure.
Diabetic Nephropathy: Irbesartan is used to slow the progression of kidney disease in people with Type 2 diabetes and high blood pressure. By reducing protein in the urine (a sign of kidney damage), Irbesartan helps protect the kidneys from further damage.
Heart Failure: In some cases, Irbesartan may also be used in conjunction with other medications to manage heart failure, although its primary indications are for hypertension and kidney protection.
Dosage and Administration
Irbesartan is typically taken orally in the form of tablets. The dosage varies depending on the individual’s condition, age, and response to treatment. For hypertension, the usual starting dose is 150 mg once daily, with a typical range of 150-300 mg per day. For diabetic nephropathy, the starting dose is also around 150 mg per day.
It's essential that the dosage is tailored to each patient, and that Irbesartan is taken as prescribed to achieve optimal results.
Side Effects and Precautions
Like any medication, Irbesartan can cause side effects. Common side effects include:
Fatigue or tiredness.
Elevated potassium levels (hyperkalemia), which can lead to serious complications if untreated.
Low blood pressure (hypotension) in some cases.
Rarely, it can lead to more severe reactions, such as allergic reactions, kidney dysfunction, or liver problems.
Patients taking Irbesartan should be regularly monitored for kidney function and potassium levels. It is also important to inform healthcare providers of any other medications being taken, as Irbesartan can interact with other drugs, such as potassium supplements or non-steroidal anti-inflammatory drugs (NSAIDs).
Conclusion
Irbesartan (CAS No. 138402-11-6) is a vital medication for managing high blood pressure and protecting against kidney damage in patients with diabetes. As an angiotensin II receptor blocker, it offers an effective treatment option for individuals with cardiovascular and renal conditions. Understanding how it works and how to use it properly can significantly improve the quality of life for patients managing chronic health issues.
Always consult with a healthcare provider before starting or adjusting any treatment regimen to ensure safety and effectiveness. Irbesartan's role in modern medicine, especially for patients with hypertension or diabetes, demonstrates the power of targeted therapies in improving patient outcomes.
URL: For more information, visit Verdant Pharma : CAS NO 138402 11 6 (IRBESARTÁN)