What Is Triple-negative Breast Cancer?

By Author: Galaxycare
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Breast cancer remains one of the most common cancers affecting women worldwide. Among its various forms, triple-negative breast cancer (TNBC) stands out for its aggressiveness and unique treatment challenges. Understanding the characteristics, risk factors, and treatment options for TNBC is crucial in managing this disease effectively. Basically, Breast cancer originates from breast cells and may develop in the ducts or lobules. It is classified based on characteristics such as hormone receptor status and HER2 protein presence, each affecting treatment approaches.

At Galaxy Care Hospital, the best Breast Cancer Hospital in Pune, we provide ongoing treatment for breast cancer patients. Our Breast Cancer Specialists navigate the challenges of Triple-Negative Breast Cancer and the ways to conquer it. Let us help you understand this rare type of breast cancer in detail. Let’s begin.

What is Triple-Negative Breast Cancer?
Triple-negative breast cancer (TNBC) lacks three key receptors: estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2), making it distinct ...
... among breast cancer types.

“Triple-negative” signifies the absence of ER, PR, and HER2 receptors, meaning TNBC does not respond to therapies targeting these receptors, unlike other breast cancers. The lack of hormone receptors and HER2 protein differentiates TNBC from hormone receptor-positive and HER2-positive breast cancers, which can be treated with targeted therapies. TNBC’s lack of targetable receptors narrows treatment options, often resulting in a more aggressive disease course and a higher recurrence risk.

Common Risk Factors of Triple-Negative Breast Cancer
Age: TNBC is more common in women under 50.
Ethnicity: Higher prevalence in African-American and Hispanic women.
Genetics: BRCA1 mutations increase TNBC risk.
High-Risk Groups Young women, certain ethnicities, and those with BRCA1 mutations are considered at high risk. For them, regular screenings and genetic counseling are recommended.

Key Symptoms and Diagnosis of TNBC
Symptoms
Symptoms are similar to other breast cancer types and include:

Lumps in the breast
Breast pain or discomfort
Changes in breast size or shape
Nipple discharge or inversion
Skin dimpling or redness
Diagnostic Methods
Early detection through regular self-exams, clinical exams can improve treatment outcomes.

Mammogram: Detects abnormalities in breast tissue.
Ultrasound: Helps distinguish solid masses from fluid-filled cysts.
Biopsy: Confirms the diagnosis and receptor status of the tumor.
Survival Rates, Aggressive Nature, and Recurrence of TNBC
Survival rates for triple-negative breast cancer (TNBC) are influenced by the stage at diagnosis, tumor size, and whether cancer has spread to other parts of the body. When caught early, TNBC patients often have a more favorable prognosis compared to cases diagnosed at an advanced stage. However, TNBC is generally more aggressive than other breast cancer types and carries a higher risk of recurrence, particularly within the first few years post-treatment. This aggressive nature contributes to a greater likelihood of distant metastasis and a potentially shorter overall survival time. Nevertheless, advancements in treatment options and early detection methods continue to improve survival rates, offering hope for better outcomes and long-term management for those diagnosed with TNBC.

Treatment Options for TNBC
The absence of hormone receptors and HER2 protein limits targeted therapy options, making TNBC more challenging to treat.TNBC treatment generally includes surgery, chemotherapy, and radiation, as TNBC responds well to chemotherapy but not to hormone-targeted therapies. Research is underway for immunotherapies and targeted therapies, with clinical trials assessing their effectiveness for TNBC.

Get Timely Treatment for Triple-Negative Breast Cancer in Pune
For those diagnosed with triple-negative breast cancer (TNBC) or any type of breast cancer, consulting a trusted healthcare provider is essential. Galaxy Care Hospital in Pune offers access to experienced breast cancer specialists and advanced oncosurgery, ensuring that patients receive the highest quality of care. Our state-of-the-art facilities and cutting-edge treatments aim to provide the best possible outcomes. If you have questions or want to schedule an appointment, please contact Galaxy Care Hospital. Together, we can navigate your path to recovery and work toward a healthier, brighter future.