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Eylea Drug Industry: Global Blockbuster Eylea Drug Gaining Widespread Acceptance For Eye Diseases

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By Author: Ben
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Introduction to Wet Age-Related Macular Degeneration and EYLEA Drug Industry

Wet age-related macular degeneration (wet AMD) is a leading cause of vision loss among elderly individuals worldwide. It is caused by abnormal blood vessel growth in the macula, the central area of the retina. These new, fragile blood vessels tend to leak fluid and blood into the macula, distorting central vision. If left untreated, wet AMD can progress and cause scarring under the macula and severe vision loss.

EYLEA (aflibercept) is a prescription medication approved for the treatment of wet AMD. It is designed to inhibit vascular endothelial growth factor A (VEGF-A) and placental growth factor (PlGF), two proteins that promote the growth of abnormal blood vessels. By blocking these proteins, EYLEA helps prevent further vision loss and may help some people gain vision. It was first approved by the FDA in 2011 and has become the leading medication for wet AMD treatment globally.

Expanding Approval for Additional Eye Diseases

In 2014, EYLEA received FDA approval for treating diabetic macular edema (DME), a leading cause of ...
... vision loss in people with diabetes. DME occurs when damaged blood vessels in the retina leak fluid and cause the macula to swell. EYLEA Drug works by blocking VEGF-A and PlGF, proteins involved in new blood vessel growth and increased vascular permeability in DME.

The drug was later approved for treating diabetic retinopathy in non-DME patients in 2017. Diabetic retinopathy involves damage to the small blood vessels in the retina over time from diabetes and can potentially progress to more advanced stages of disease like DME. EYLEA helps manage the disease by inhibiting VEGF and related factors implicated in its pathology.

In 2018, EYLEA gained approval for treating macular edema following retinal vein occlusion (RVO). RVO blocks or slows the flow of blood out of the eye through retinal veins, causing fluid accumulation and swelling of the macula. EYLEA helps resolve edema by blocking VEGF's effects on increased vascular permeability and blood vessel growth in RVO.

Global Sales and Clinical Evidence Supporting EYLEA Drug Industry Efficacy

Commercial success: EYLEA has grown to become one of the top selling ophthalmic drugs globally. In 2021, its maker reported over $7 billion in annual worldwide sales, making it the second highest revenue generator for its parent company. A majority of sales still come from wet AMD treatment in the US, Europe, and Japan.

Clinical trial results: Numerous Phase 3 trials have demonstrated EYLEA's efficacy and safety profile for its approved eye conditions. In wet AMD, it has shown ability to maintain or improve vision for two years in over 90% of patients. In DME, roughly 40-50% of patients gained at least 15 letters of vision after two years. For RVO, it led to rapid and sustained improvements comparable to other treatments. Overall, EYLEA has set the benchmark for efficacious VEGF inhibition in retinal vascular diseases.

Real-world evidence: Large observational studies on EYLEA's use in clinical practice reaffirm its benefits. Analysis of over 30,000 Medicare patients found significantly better visual outcomes with EYLEA versus other anti-VEGF drugs for wet AMD and DME. Studies from nationwide registries also report high rates of maintained or improved vision among patients receiving EYLEA in routine care settings.


In summary, EYLEA has rapidly gained worldwide recognition as the premier anti-VEGF treatment for major retinal vascular diseases due to its demonstrated superiority over alternatives. Supported by robust clinical data, healthcare systems increasingly favor reimbursement for EYLEA given its ability to prevent blindness and restore vision better than other options. As the global population ages and rates of diabetes rise, EYLEA will likely remain indispensable for managing the vision impacts of wet AMD, DME, and related conditions for many years to come.

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