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Tesamorelin Effects On Hiv Patients
Tesamorelin is a synthetically produced peptide that mimics a growth hormone releasing hormone. It has shown promise in reducing visceral adipose tissue (VAT) in HIV patients. A research study focused on analyzing patients receiving tesamorelin for twenty six weeks in a Phase III clinical trial.
The data was carefully compared between patients with and without dorsocervical fat caused by a tesamorelin response. Among these patients, VAT and waist circumference decreased, showing that this peptide is effective and should be considered as a potential treatment for excess visceral adipose tissue whether dorsocervical fat is present or not.
Lipodystrophy is fat distribution, along with metabolic disorders. They include lipohypertrophy and lipoatrophy. Lipoatrophy is when there is fat loss around the face, limbs and buttocks, while lipohypertrophy is fat deposits in the abdominal visceral adipose tissue, dorsocervical area and breasts. It is common in patients with HIV that have been treated with antiretroviral therapy, which then results in HIV associated lipodystrophy.
There re many factors that play a role ...
... in lipdystrophy in patients with HIV, including their viral load, nadir CD4 count and the type of antiretiroviral therapy they are receiving. The common side effects of this condition includes impaired growth hormone secretion, adiponectin deficiency and abnormal leptin regulation.
In addition to traditional HIV associated lipodystrophy, visceral adipose tissue has also been identified as part of antiretroviral therapy weight gain. This weight gain was thought to be attributed to the phenomenon, known as “return to health, which is associated with immunologic recovery. Weight gain has also been seen in patients on stable antiretinoviral regimes when switching to the new classes of medication.
Recent studies have proven that weight gain is associated with modern antiretinoviral therapy. A South African study, that was a ninety six week study, showed more weight gain in the arms, the weight gain was associated with VAT increase, which was a result of ART.
There are treatments for lipodystrophy, including using the peptides tesamorelin, which has been FDA approved for the reduction of visceral adipose tissue. This peptide has shown great promise in reducing visceral adipose tissue quantity, while improving the quality. Unfortunately there are not enough studies to show how tesamorelin impacts VAT in patients with different types of lipodystrophy.
Tesamorelin has shown to reduce visceral adipose tissue in a phase III clinical study, when compared to a placebo. The study proved that the patients receiving the peptide had VAT reductions by the twenty sixty week and these reductions were maintained until the fifty second week. The peptide was well tolerated without changes to glucose levels.
It was also identified that patients with baseline metabolic syndrome, where white race or had elevated triglyceride levels were more likely to see a reduction in VAT after a six month period of being on a tesamorelin therapy. The study didn't study how ectopic fat was impacted.
The current data that was collected showed that tesamorelin can be effective to reduce visceral adipose tissue in patients with HIV, whether they have dorsocervial fat deposits or not. Patients without dorsocervial vat had extra reductions in SAT and limb fat by the twenty sixth week, but the metabolic measurements were similar.
The study did not include how lipoatrophy impacted the tesamorelin response. There are still many questions that need answering regarding visceral adipose therapy deposits and treatments in HIV patients, along with lipoatrophy and lipohypertrophy.
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