123ArticleOnline Logo
Welcome to 123ArticleOnline.com!
ALL >> General >> View Article

Rznomics: Circular Rna Platform Tech

Profile Picture
By Author: Ben Gross
Total Articles: 460
Comment this article
Facebook ShareTwitter ShareGoogle+ ShareTwitter Share

Rznomics, a biopharmaceutical company, has developed a groundbreaking 'self-circularized RNA structure' platform technology that efficiently generates circular RNA, overcoming the limitations of existing methods.

Circular RNA (circRNA) offers improved stability against nucleases and minimal unwanted immune responses, making it an attractive candidate for vaccines and therapeutics. Rznomics' technology utilizes a unique Tetrahymena trans-splicing ribozyme platform to convert linear RNA into circular RNA through an end-to-end self-targeting and splicing (STS) reaction. Unlike other methods, Rznomics' circularization does not leave unnecessary genetic information in the gene of interest (GOI). The efficiency of the self-circularization process is comparable to other methods, and various optimization strategies can be employed to increase its efficacy, even with long RNA molecules.

The significance of Rznomics' technology lies in its potential for commercialization, enabling more competitive pricing for circRNA vaccines or therapeutics while maintaining efficacy. In vitro transcription initiates the self-circularization ...
... reaction simultaneously, streamlining the purification process. The purified circRNA demonstrates sustained protein expression without unwanted immune responses, outperforming linear RNA with modified nucleotides.

The research was supported by the Ministry of Science & ICT and the National Research Foundation of Korea. Rznomics holds a patent for the 'Self-circularization RNA structure and Platform technology' in South Korea, with applications submitted in the U.S. and other major countries.

Rznomics is a biopharmaceutical company focused on RNA-based gene therapeutic bio-drugs for cancer and incurable diseases. Their core platform technology utilizes an RNA replacement enzyme, trans-splicing ribozyme, to selectively induce therapeutic gene activity in cells expressing target RNA. The company's lead candidate, RZ-001, is intended for treating Hepatocellular Carcinoma & Glioblastoma, with other treatments in the pipeline for Alzheimer's disease and hereditary retinal dystrophy.

More Information : https://www.techdogs.com/tech-news/pr-newswire/rznomics-presents-its-own-circular-rna-platform-technology

Total Views: 249Word Count: 272See All articles From Author

Add Comment

General Articles

1. Neotonics: A Comprehensive Review Of The Skin And Gut Health Supplement
Author: Neotonics: A Comprehensive Review of the Skin and

2. Why Maintain Your Car Properly?
Author: Anthea Johnson

3. How Seva In Dharma Makes The World A Better Place
Author: Chaitanya Kumari

4. British And Irish Lions: Aunz V Lions Test Add On The Line
Author: eticketing.co

5. What Is Kpi And Kra? A Complete Guide To Performance Management Metrics
Author: TrackHr App

6. A Complete Guide To The Best Schools In Bhopal For Academic Excellence
Author: Ronit Sharma

7. British And Irish Lions 2025: Fans React To Shock Omissions
Author: eticketing.co

8. A Complete Guide To Installing Meter Boxes Safely And Correctly
Author: adlerconway

9. Your Shortcut To Smarter Learning
Author: coursefpx

10. Unencumber A Logo-new Way Of Life At Krisala 41 Commune Wakad: Wherein Luxurious Meets Clever Residing
Author: Armaan

11. Headless Wordpress As An Api For A Next.js Application
Author: brainbell10

12. Firebase And Crashlytics In Flutter And Swift
Author: brainbell10

13. Guide To Replacing And Maintaining Backhoe Loader Hydraulic Cylinders
Author: Seetech Parts

14. What Is The Difference Between On-grid, Off-grid, And Hybrid Solar Systems?
Author: Vishtik

15. Mobile Internet Usage Growth In Usa
Author: Jenny Knight

Login To Account
Login Email:
Password:
Forgot Password?
New User?
Sign Up Newsletter
Email Address: