Non-surgical Treatment For Parkinson Disease

By Author: mrgfus
Total Articles: 2
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Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons in the midbrain. Its cardinal motor symptoms include tremor, rigidity, bradykinesia/akinesia, and postural instability. Brain stimulation is one of the fastest-growing neuroscience areas involving medical and bioengineering fields. Brain stimulation is inherently non-destructive, reversible, and, most importantly, adjustable. Whether invasive or non-invasive, the electrical intervention can modulate the nervous system function, leading to improved neurological symptoms and better quality of life. Pharmacotherapy is the mainstay treatment for patients with PD, and levodopa is the most effective drug for managing motor symptoms However, side effects such as dyskinesia and the on/off phenomenon have been associated with levodopa treatment. Moreover, its effectiveness has decreased over the years. Deep brain stimulation has been clinically useful in the treatment of PD at all stages, especially in those patients with motor symptoms only partly controlled by dopaminergic drugs, such as severe rest tremor or off-period ...
... dystonia, and motor fluctuations. However, many DBS issues remain challenging, for instance, choosing a suitable stimulation target to maximize clinical outcomes, while minimizing side effects. As a highly heterogeneous disease, one DBS solution does not fit all patients. Non-surgical treatment for Parkinson disease is especially used for to cure tremors.
Invasive surgical alternatives to pharmacological treatments include stereotactic thalamotomy, deep brain stimulation (DBS), spinal cord stimulation (SCS), and continuous infusion of levodopa-carbidopa or apomorphine therapy. DBS is a widely used medical device therapy and surgical standard for patients with Parkinson disease. The use of SCS in patients with Parkinson disease is promising for relieving concurrent pain conditions. The delivery of Duodopa intestinal gel directly into the small intestine reduces fluctuating motor symptoms and improves the quality of life. However, the risk associated with the implantation of these invasive medical devices is a burden for patients with Parkinson disease. For example, DBS may cause irreversible intracranial hemorrhages. Mrgfus RoyalCare is Parkinson's treatment, Best Neuroscience department in Coimbatore. Non- surgical treatment for Parkinson disease technique allows for incision-less Coimbatore. It is the only Neuro-Care center in all of India, facilitated with expertise and technology that provides a Non-surgical treatment for Parkinson’s disease.
The procedure uses focused beams of ultrasonic energy guided by MRI to target areas deep in the brain with no incisions or permanent implants. MRgFUS procedure does not require general anaesthesia. It makes it viable and safer for patients with kidney or heart problem who are unfit for general anaesthesia and on the same ground, face problems while undergoing regular surgeries. However, it has been associated with variable efficacy and a relatively high incidence of adverse effects. MRgFUS is exactly like the radiation in one sitting of one hour and you completely destroy the tremor and pain also disappears. MRgFUS is used for to treat Parkinson’s patients with tremors and we are going to treat the centres that cause tremors without opening the skull just by sending sound radiation. It will enable us to perform brain surgeries without even touching the patient. Different surgeries of the brain can be performed using MRgFUS without opening the skull. MRgFUS brain module will perform surgeries of brain tumors, Parkinson’s disease tremors.
The magnetic resonance enables the doctor to detect the tremor and the surroundings in 3D, it also helps in getting a real time knowledge about the temperature changes in the treated areas and observe what has been treated. At a lower energy, MRgFUS can disrupt the blood-brain barrier to allow passage of drugs. This focal disruption of the barrier can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the blood brain barrier are invasive, as the blood brain barrier is relatively impermeable to systemically delivered antineoplastic agents. MRgFUS has great potential to enhance brain tremor drug delivery, while limiting treatment toxicity to the healthy brain.