Pros & Cons Of The Wet Granulation Process

By Author: John
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Granulation is the process of forming granules or grains from a powdered medicine or drug or any solid substance. In this article, we are going to talk about the wet granulation equipment and the pros and cons of the wet granulation process. So let us dive right into the multiple pros and cons of the wet granulation process and what are the key applications of the wet granulation process.

There are many advantages of the wet granulation process. Let us discuss these pros of wet granulation process in detail -

It improves the drift residences of materials - In this granulation approach, you can, without any hindrances, increase the granule length or size with the moisture content material. As an end result, it is less difficult to increase the flowability of the final granule. For instance, you may undertake this granulation process to grow the flowability of microcrystalline cellulose.
Improves the compression of materials and its densification characteristics - You can easily produce very dense granules with the help of an excessive shear mixer or granulator.
Obtaining a homogenous mixture is straightforward ...
... - From the rotating impeller to adding granulation liquid, you may without problems produce homogenous granules. This is because the motion of high shear granulation machines makes it less complicated for a good and higher distribution of particles.
Reduces air pollution - Both aqueous solutions and natural solvents reduce dust, that could in any other case cause air pollution. Remember, those granulation solutions also dispose of any viable generation and accumulation of static charges. In addition to these charges, the granulation manner reduces cross contamination and lets in for better powder coping without compromising on homogeneity. The present day wet powder granulation procedure is more cost saving and rather efficient than the old techniques. This makes it a really perfect choice for quite a number of fabric processing approaches within the pharmaceutical industry.
Improved compressibility of powders on account of moist granulation manner lets in using low pressure all through compression. This reduces gadget put on and as a result improves the existence of the machine.
The wet granulation process guarantees higher content material uniformity, specially for soluble low-dose drugs.
The system makes use of conventional excipients and therefore isn't always dependent on the inclusion of special grades of excipients.

On the other hand, there are a few cons of the wet granulation process with the help of wet granulation equipment too. Let us discuss these cons in detail -

Long and lengthy process - There are multiple steps in the wet granulation process.
Not very cost-effective - The wet granulation process is not very cost-effective as it requires a lot of time, labour, energy, equipment and space area for the process.
Unsafe for the environment - Migration of soluble dyes may occur during the drying process.
Impending slowing down of process - The dissolution rate of tablets manufactured by wet granulation may decrease with aging.
Possible loss of material - Due to the long process and numerous steps, a lot of material can be lost in the wet granulation process.
Very tedious and complicated process - The wet granulation process involves many procedures which makes it super cumbersome to control.
Higher Initial costs - The initial installation costs can be extremely expensive and time consuming, not to forget that the machineries also take up a lot of ground space.

You can look for granulator machines for pharmaceuticals at any leading pharmaceutical equipment manufacturers. Check out their website and make an informed decision on which granulator machine for pharmaceuticals is apt for your purpose.