Enhancing Ketosis Faq

By Author: Zachary Cain
Total Articles: 1
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This page is very science-heavy, but it explains in detail how we achieve the amazing results we do. Most sections have a link to the full article, which typically has much more information that what is listed below.

For more basic information or information about ketogenic diets in general, please see the Ketosis Q&A page.
Please see the Science Page to learn more about the different ingredients and how each one impacts ketosis. There are links to multiple studies for each ingredient there as well as the science behind our other products.

What is dietary ketosis?

The science of dietary ketosis is complicated. Ketogenic diets are not. Unfortunately, that doesn’t make them easy. The diet Western cultures have adopted relies heavily on carbohydrates as an energy source.
Trying to dramatically decrease the carbohydrates you ingest is difficult, not only because you have to learn about the carbohydrates content of each meal, but because of the emotional stress of trying to stick to a new diet.
Although complicated at the biochemistry level, at a basic level, ketosis is just a switch ...
... in the fuel source your body uses. Without enough carbohydrates coming from your diet, and once you’ve burned through your body’s storage, your body starts making ketones from the fats you eat. Ketones become the new fuel source for the body.
Without enough fat in your diet to meet all your caloric needs, your body starts burning through its fat stores. That is why ketogenic diets are famous for fat / weight loss.
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Keeping the kidneys from reabsorbing glucose to enhance ketosis
During normal physiological conditions, almost 100% of glucose passing through the kidneys is reabsorbed and remains in the blood. SGLT1 does about 10% of the work, but the rest is done by SGLT2 in the kidney.

When blood glucose is high,
SGLT2 will stop transporting glucose back into the blood and let it escape into the urine. By using an SGLT2 inhibitor, diabetics can lower their blood sugar. From a ketogenic standpoint, SGLT2 inhibitors do the same thing as they do in diabetic patients.
By targeting SGLT2 around the same time as glucose enters the system (meals), you can decrease the total amount of glucose in the system during the post-prandial time, so it is highly effective at reducing overall blood glucose levels.

Although a good target, there is a risk when allowing glucose to escape in the urine. Urinary tract infection bacteria love glucose, so there is a risk that feeding them may lead to infection. However, if only used occasionally, this should be a minimal risk.
Do keto pills work?

Prior to KetoSavior™ and KetoGuardian™, there were only two types of keto supplements: exogenous ketones and starch blockers. Exogenous ketones may have a place during the Induction Phase of ketogenic diets (see “Should I take exogenous ketones?”), which typically lasts until around day 4 of the diet, but should not be used to enhance ketosis, despite being marketed as such.

Starch blockers can enhance ketosis during “cheat days” and meals containing large amounts of starch, but most people on ketogenic diets don’t have much use for them. Blocking the breakdown of starch into smaller digestible sugars would be beneficial to reducing blood glucose and insulin secretion, but starchy vegetables are considered “bad” carbohydrate sources, so aren’t consumed in large quantities on the diet anyway.

At best, starch blockers can have an effect on only part of one of the four processes used to enhance ketosis. It will suppress starch breakdown which will suppress SOME of the carbohydrates absorbed by the intestines, however, these only help with starch and have no effect on simple sugars or starch breakdown products, or any other target for enhanced ketosis.

Until now, there was nothing on the market that could target the other three biological processes that can be utilized to enhance ketosis (see the Enhancing Ketosis FAQ page). However, there is plenty of research in the scientific literature that describes botanical extracts and how they impact these processes.

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