Chemical Glycine Ethyl Ester Hydrochloride Characteristics

By Author: ada red
Total Articles: 85
Comment this article

CAS No:623-33-6
Formula:C4H10ClNO2
Synonyms:GEE;usafdo-10;Gly-OEt HCl;H-GLY-OET HCL;GLYCINE-OET HCL;GLYCINE ETHYL ESTER;RARECHEM AL BW 0032;ETHYL AMINOACETATE HCL;Glycine ethylester HCI;GLYCINE ETHYL ESTER HCL

Chemical Glycine ethyl ester hydrochloride Description
Crystalline

Chemical Glycine ethyl ester hydrochloride Basic Attributes
CAS No：623-33-6

Molecular Formula ：C4H10ClNO2

Molecular Mass ：139.58

Exact Mass ：154.050903

PSA ：52.3 A^2

EINECS ：210-787-4

InChIKeys ：TXTWXQXDMWILOF-UHFFFAOYSA-N

H-bond Acceptor ：3

H-bond Donor ：2

SP3 ：0.75

RBN ：3

Chemical Glycine ethyl ester hydrochloride Characteristics
Appearance ：White Crystalline Powder

Density ：1 g/cm3

Melting Point ：145-146 °C(lit.)

Solubility ：H2O: >1000 g/L (20 ºC)

Storage Condition ：Store at RT.

BRN ：3594034

Chemical Glycine ethyl ester hydrochloride Safety Information
HS Code ：29224995

UN No. ：NONH for all modes of ...
... transport

WGK_Germany ：3

Risk Code ：41-36/37/38

Safety Instructions ：26-39-24/25-37/39

RTECS No. ：MC0525000

Dangerous Mark ：Xi

P Code ：P280-P305 + P351 + P338

Hazard Statements ：H318

Chemical Glycine ethyl ester hydrochloride Product Usage
A Glycine (G615990) ester used as parakeratosis inhibitor and external composition for skin.

Chemical Glycine ethyl ester hydrochloride Production Methods
Can be prepared with glycine or chloroacetic acid as raw materials. It is described as follows. Glycine is used as the raw material method. Dry hydrogen chloride gas is passed into absolute ethanol to make hydrogen chloride ethanol solution, then glycine is added, heated and stirred for esterification, and the reaction temperature is controlled at 80-85°C. After all the glycine is dissolved, stirring A few minutes, while hot, move the reaction solution to the crystallization pot, cool the crystallization, and filter to obtain ethyl glycine hydrochloride. Reaction equation: NH2CH2COOH+C2H5O[HCl]→NH2CH2COOC2H5·HCl can also be added to the reactor with stirring glycine and absolute ethanol, heated to 60 ℃, through the introduction of hydrogen chloride gas, hydrogen chloride until the reactants are completely dissolved, continue After passing hydrogen chloride to recrystallization, it is the end point. The reaction solution is transferred to the crystallization pot, while stirring, the crystal is cooled and filtered, washed with absolute ethanol, and dried to obtain ethyl glycine hydrochloride. Chloroacetic acid is used as the raw material method. Chloroacetic acid, urotropine and absolute ethanol are added to the reactor. At 45℃, ammonia gas is passed to make pH=8～8.5. The rate of ammonia gas is controlled to maintain the reaction temperature at Between 40 and 65°C, after the ammonia gas has been passed through, the reaction is held at 65°C for 1 hour, then the temperature is reduced to 30°C, and the hydrogen chloride-anhydrous ethanol solution is added dropwise. After the dropwise addition, react at 70℃ for 2h, then filter hot at 62～65℃ to separate the ammonium chloride crystals. The filtrate is placed in a crystallization pot, cooled to 10℃, crystallized while stirring, the crystals are filtered, Dry to give ethyl glycine hydrochloride. Reaction equation: ClCH2COOH+NH3[ethanol]→NH2CH2COOH[C2H5OH]→[HCl]NH2CH2COOH·HCl