Chemical Products (r)-benzyloxymethyl-oxirane Material And Products

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CAS No: 14618-80-5
Formula: C10H12O2
China Export: From 2018.11 to 2019.11, total export volume of (R)-Benzyloxymethyl-oxirane from China was 13,136,469KG while total export value was $93,749,048. The biggest proportion of exporting volume in the last 12 months was 12.79% in 2019.03.

Chemical Products (R)-Benzyloxymethyl-oxirane Basic Attributes
CAS No：14618-80-5

Molecular Formula ：C10H12O2

Molecular Mass ：164.2

Exact Mass ：164.083725

PSA ：21.8 A^2

LogP ：1.3

InChIKeys ：QNYBOILAKBSWFG-JTQLQIEISA-N

H-bond Acceptor ：2

H-bond Donor ：0

SP3 ：0.40

RBN ：4

Chemical Products (R)-Benzyloxymethyl-oxirane Characteristics
Density ：1.077

Bolling Point ：130 °C (0.1 mmHg)

Flash Point ：>230 °F

Refractive Index ：1.517

Solubility ：soluble in water.

Storage Condition ：2-8°C

BRN ：3588399

Specific Rotation ：-5.4 º (c=5 in toluene)

Chemical Products (R)-Benzyloxymethyl-oxirane Safety Information
HS Code ...
... ：2910900090

UN No. ：NONH for all modes of transport

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：26-36-37/39

RTECS No. ：TX2860020

Dangerous Mark ：Xi

P Code ：P261-P305 + P351 + P338

Hazard Statements ：H315-H319-H335

Chemical Products (R)-Benzyloxymethyl-oxirane Product Usage
Used in the preparation of lactone fragments of compadine and lovastatin. 1 Preparation of cis-1,3-polyol, 2 dideoxy nucleoside 3 and spiroacetal cyanohydrin chiral.

Chemical Products (R)-Benzyloxymethyl-oxirane Production Methods
Under an argon atmosphere, to a suspension of NaH (179 mg, 4.10 mmol, 55percent in oil) in THF (2 mL) were sequencially added a solution of (S)-glycidol (S1, 200 mg, 2.70 mmol) in THF (4 mL), and benzyl bromide (0.340 mL, 2.86 mmol) at 0 °C. After the mixture was stirred for 19 h under reflux, the reaction was quenched with 0.1 M phosphate buffer (pH 6.5). The products were extracted with AcOEt (x3), and the combined organic layer was washed with brine, then dried over Na(R, R)-N, N-Bis-(3, 5-di-tert-butylsalicyclidene)-1, 2-cyclohexanesanediaminocobalt (II) (0.029 g, 0.05 mmol) was added to a mixture of 2-((benzyloxy)methyl)oxirane (1.63 g, 9.91 mmol), AcOH (0.011 mL, 0.198 mmol) and THF (0.15mL). The mixture was cooled to 0 °C and treated with H0.5 mole of racemic 1, 2-epoxy compounds were added with 0.4 mole percent of the catalyst prepared in Preparation [(1-RR)-(Dibenzoyl-LTA) ] (or Preparation [ (1-SS) - (Dibenzoyl- DTA)]) and cooled down to 5 To a stirred solution of(S)-glycidol (5 g, 67.5 mmol) and benzyl chloride (13 g) in DMF (40 mL) cooled at 0 °C was added a powder of NaH (2.4 g) slowly for 10 minutes.

Chemical Products (R)-Benzyloxymethyl-oxirane Material and Products
Material ：
N,N-Dimethylformamide, (S)-Oxiranemethanol, BENZYLGLYCIDYLETHER, ALLYL BENZYL ETHER, Petroleum Ether, Ethyl Acetate, Benzylbromide, Sodium Hydride