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Bac Library Construction For High Quality Advance Genomic Research

By Author: Brian Diesel
Total Articles: 31

The significance of BAC Library Construction

BAC - bacterial artificial chromosome is based on a practical fertility plasmid which is widely used for altering and cloning in bacteria. They contain partition genes which are useful in promoting the even distribution of plasmids post the cell division process.

An undersized sample of DNA is amplified in the form of an insert in BACs which is then sequenced and rearranged in silico for getting the final genomic sequence of any organism.

BACs is used in modeling genetic diseases and has proved to be extremely useful in studying complex genes having numerous regulatory sequences including various promoter sequences which govern a gene's expression level. They hve proven efficiacy in investigating diseases like Alzheimer's and Down syndrome apart from specific oncogenes using electroporation.

BACs aid the detection of large sequences and mapping of human chromosome using as they are capable of accommodating large sequences without rearranging and remain stable in cloning vectors.

The enormous knowledge and detailed study in the area of genomics have promising rewards for medical sciences and health remedies. Now almost all diseases have found a cure and this is made possible only due to genetic experiments.

Out of the several inventions and improvements made in the sector of genomic research, a remarkable and note worthy technology that stands apart is Bacterial Artificial Chromosome (BAC) library screening and has proved to be instrumental in gene identification.

It can simultaneously host one million large DNA fragments in a stable sample of E. coli and is useful for procedures such as genome wide gene mapping, sequencing as well as chromosome walking. The team of specialists at CD genomics have constructed several libraries using different species.

The numerous applications of BAC Library Construction

Large genomic DNA insert-containing libraries are required as critical tools for physical mapping, positional cloning, and genome sequencing of complex genomes. The bacterial artificial chromosome (BAC) cloning system has become a dominant system over others as it can efficiently clone large genomic DNA inserts. The CD Genomics laboratory has constructed many high-quality deep-coverage large insert BAC libraries.

Our highly versatile, reliable, accurate and advanced tools can build a BAC DNA library using a massive variety of materials. BAC Library Construction service has several benefits including precision, faster turnaround time, competitive packages and custom made solutions that allow you to attain your research goals as early as possible. At CD Genomics we make sure that researchers get the best results speedily so that you can focus on other studies. Be sure to check online for all the service providers so that you can an informed choice.

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