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Ampicillin Is A Semi-synthetic Penicillin - Pillsformedicine
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Ampicillin is a penicillin antibiotic that is used to treat certain types of bacterial infections. It works by killing certain types of bacteria.
Mechanism of action :
Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. It differs from penicillin only by the presence of an amino group. That amino group helps the drug penetrate the outer membrane of gram-negative bacteria.
Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis. It has received FDA approval for its mechanism of action.
Treatment of infections caused by susceptible strains of Shigella, Salmonella, E. coli, H. influenzae, P. mirabilis, N. gonorrhoeae, enterococci, gram-positive organisms (penicillin G–sensitive staphylococci, streptococci, pneumococci)
Meningitis caused by Neisseria meningitidis
Unlabeled use: Prophylaxis in cesarean section in certain high-risk patients
Drug interactions :
Increased ampicillin effect with probenecid
Increased risk of rash with allopurinol
Increased bleeding effect with heparin, oral anticoagulants
Decreased effectiveness with tetracyclines, chloramphenicol
Decreased efficacy of hormonal contraceptives, atenolol with ampicillin
Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:
are allergic or sensitive to or have had a bad reaction to beta-lactam antibiotics such as penicillin or cephalosporins
are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
are on dialysis
have certain types of infections
have certain types of leUSAaemia
have kidney problems
have or have had allergies
Side Effects :
Common side effects of this drug include nausea, vomiting, loss of appetite, diarrhea, abdominal pain, rash, itching, headache, confusion and dizziness. Patients with a history of allergic reactions to other penicillins should not receive ampicillin. Persons who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins, for example, cefaclor (Ceclor), cephalexin (Keflex), and cefprozil (Cefzil), may or may not be allergic to penicillins. Serious but rare reactions include seizures, severe allergic reactions (anaphylaxis), and low platelet or red blood cell count. Ampicillin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting ampicillin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
Missed dose :
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Store at room temperature between 59-86 degrees F (15-30 degrees C), away from excessive heat and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
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